Sure, I'll help you with the exercises. Let's start with filling in the blanks using "Although" and "Despite":

1. **Although** he was brave, he cannot sleep in that scary house alone.
2. **Although** she is kind to everyone, she still has a few enemies.
3. **Although** he is wise, he sometimes makes foolish mistakes.
4. **Although** he was strong, he couldn't lift the heavy box alone.
5. **Although** he is patient, he cannot wait for her for more than 2 hours.
6. **Although** he is honest, he sometimes has trouble expressing his true feelings.
7. **Although** she was beautiful, she never relied on her looks to get ahead in life.
8. **Although** the painting was ugly, it still managed to capture the artist's emotions.
9. **Although** she came from a poor family, she never let her financial circumstances limit her dreams and aspirations.

Now, let's handle the conjunction exercises:

1. It's raining outside. **Therefore**, we decided to cancel our picnic plan.
2. John loves to eat pizza, **although** he knows that it's not very healthy.
3. **Although** Maria works hard to improve her skills, she is very talented.
4. Jack studied hard for his exam. **Therefore**, he got a good grade.
5. The restaurant was very crowded. **Therefore**, we had to wait for a table.
6. The movie was really long. **However**, we still enjoyed it.
7. I love to swim **despite** I'm afraid of deep water.
8. **Although** he studied very hard, he still failed the exam.
9. The weather was really bad. **Despite** we decided to go hiking anyway.
10. **Although** she was sick, she still went to work.
11. John loves playing basketball. **However**, he rarely has time to practice.
12. **Despite** the bad weather, the school decided to keep classes open.
13. **Although** he is very rich, he doesn't like to buy expensive things.
14. I enjoy listening to music. **However**, I can't listen to it while I'm studying.
15. Sarah wants to visit the museum. **However**, she doesn't have enough money to pay for a ticket.
16. **Because of** the noise, the baby couldn't sleep.
17. She studied hard for the exam, **therefore** she got an A.
18. The hotel had a great location, **but** the room was small.
19. **Despite** the long queue, she waited patiently to buy the tickets.
20. **Despite** he was afraid of heights, he still went bungee jumping.
21. It was raining outside, **therefore**, we decided to stay indoors.
22. **Despite** the high price, the product sold well in the market.
23. She was tired, **but**, she couldn't fall asleep.
24. **Despite** the weather was bad, they still went camping.
25. **Like** my brother, I love soccer.
26. The weather was beautiful, **but**, I didn't feel like going outside.
27. The train was delayed **because of** there was a problem on the tracks.
28. The restaurant had great reviews, **but** the service was disappointing.
29. Peter was tired, **so** he went to bed early.
30. The kids couldn't play outside **because of** it was raining heavily.
31. **Despite** the lack of experience, he managed to get the job.
32. **Despite** the heavy rain, John still went for a run.
33. Sarah was feeling sick, **but** she went to work anyway.
34. **Despite** her efforts, she couldn't finish the project on time.
35. The weather was hot, **so** we still went for a walk.
36. The project was challenging, **however**, the team managed to complete it on time.
37. He studied hard for the test, **however**, he still didn't pass.
38. She didn't want to eat the cake **because** she was on a diet.
39. He slept late last night, **therefore**, he was tired this morning.
40. The restaurant was busy, **but** the food was served quickly.
41. He is usually a careful driver, **but** he got into an accident yesterday.
42. **Although** they had been dating for years, they decided to break up.
43. We had a lot of work to do, **therefore**, we decided to stay late at the office.
44. **Despite** the fact that she was sick, Sarah went to work.
45. **Despite** she didn't have much experience, she got the job.
46. Max didn't study for the test **because** he thought it would be easy.
47. She didn't exercise regularly, **therefore**, she gained weight.
48. **Despite** his busy schedule, Tom managed to complete the project on time.
49. **Although** the movie received bad reviews, it was still very popular.
50. **Like** my mom, I hate to eat sushi.
51. **Despite** its expensive price, he decided not to buy the car.
52. The car was old, **but** it still ran well.
53. The restaurant was full, **so** we had to go to another one.
54. **Although** he tried his best, he couldn't finish the race.
55. **Because of** the lack of time, she cannot finish her work.
56. The music was loud, **but** we still had fun at the party.
57. **Despite** the noise, he managed to fall asleep quickly.
58. **Although** they had a lot of money, they were still unhappy.
59. **Like** his father, he became a teacher.
60. **Although** it was raining, we decided to go for a walk.
61. Sarah couldn't attend the concert **because** she was feeling sick.
62. John was late for his exam **because** his car broke down on the way to school.
63. I know you're busy, **however**, can you help me with this task?
64. **Although** she had a lot of experience, she was still nervous for the interview.
65. **Despite** she was feeling sick, she still went to school.
66. Mark had to cancel his trip **because** his flight was cancelled due to bad weather.
67. **Because of** the noise, he couldn't work.
68. The store was busy, **but** we still found what we needed.
69. The house was small, **but**, it was cozy and well-decorated.
70. **Despite** the bad traffic, he arrived on time for the meeting.
71. **Because of** the snow, school was cancelled.
72. I won't be able to come to the party **because** I have a lot of work to do.
73. **Despite** the traffic jam, she arrived late to the meeting.
74. The traffic was heavy, **but** we arrived on time.
75. She had a lot of experience, **but** she didn't get the job.
76. The product was expensive, **however**, it was of great quality.
77. **Although** he didn't have a lot of time, he still managed to finish the project.
78. The car ran out of gas, **therefore**, we had to walk to the gas station.
79. Rachel didn't want to go to the beach **because** she doesn't like the sun.
80. **Despite** the long wait, they decided to leave.
81. The restaurant had great food, **but** the service was terrible.
82. I have an early flight tomorrow, **so** I have to go to bed early.
83. He missed his train, **therefore** he arrived late to the meeting.
84. The exam was difficult, **but** she managed to get an A.
85. **Although** he was short, he was great at basketball.
86. **Because of** the delay, they missed their flight.
87. The cat knocked over the vase **because** it was chasing a mouse.
88. He didn't pass the test **because** he didn't study enough.
89. Jack was tired, **but** he still went for a run.
90. **Despite** her fear of heights, Lisa went bungee jumping.
91. **Although** she was tired, she continued to work.
92. Tom was late for the meeting **because** his car got a flat tire.
93. He didn't want to go to the party **because** he didn't like the host.
94. The concert was sold out, **therefore**, we couldn't get tickets.
95. The book was long, **but** it was a great book.
96. **Despite** the bad reviews, the restaurant was crowded.
97. The apartment was small, **but** it was in a great location.
98. Emma studied hard, **so** she passed the exam.
99. The weather was hot, **so** we decided to go swimming.
100. She didn't eat breakfast, **therefore**, she was feeling hungry.
101. The store was closed **because** it was a holiday.
102. **Because of** the bad smell, they left the room.
103. **Despite** the heavy rain, they stayed home.
104. He didn't have enough money, **so** he couldn't buy the expensive watch.
105. Susan studied for hours, **but** she still couldn't solve the math problem.
106. I can't come to the meeting **because** I have another appointment.
107. The hotel was fully booked, **therefore**, we had to find another place to stay.

Here are the sentences transformed into "Although" and "Despite" as requested, followed by answers to the multiple choice questions.

### Transformations:
1. **Although he was brave, he cannot sleep in that scary house alone.**
2. **Although she is kind to everyone, she still has a few enemies.**
3. **Although he is wise, he sometimes makes foolish mistakes.**
4. **Although he was strong, he couldn't lift the heavy box alone.**
5. **Although he is patient, he cannot wait for her for more than 2 hours.**
6. **Although he is honest, he sometimes has trouble expressing his true feelings.**
7. **Although she was beautiful, she never relied on her looks to get ahead in life.**
8. **Although the painting was ugly, it still managed to capture the artist's emotions.**
9. **Although she came from a poor family, she never let her financial circumstances limit her dreams and aspirations.**

### Multiple Choice Answers:
1. **A. Therefore** (It's raining outside. **Therefore**, we decided to cancel our picnic plan.)
2. **A. Although** (John loves to eat pizza, **although** he knows that it's not very healthy.)
3. **D. Because** (**Because** Maria works hard to improve her skills, she is very talented.)
4. **B. Therefore** (Jack studied hard for his exam. **Therefore**, he got a good grade.)
5. **D. Therefore** (The restaurant was very crowded. **Therefore**, we had to wait for a table.)
6. **C. However** (The movie was really long. **However**, we still enjoyed it.)
7. **D. Although** (I love to swim **although** I'm afraid of deep water.)
8. **D. Although** (**Although** he studied very hard, he still failed the exam.)
9. **C. Despite** (The weather was really bad. **Despite** we decided to go hiking anyway.)
10. **D. Although** (**Although** she was sick, she still went to work.)
11. **C. However** (John loves playing basketball. **However**, he rarely has time to practice.)
12. **B. Despite** (**Despite** the bad weather, the school decided to keep classes open.)
13. **B. Although** (**Although** he is very rich, he doesn't like to buy expensive things.)
14. **C. However** (I enjoy listening to music. **However**, I can't listen to it while I'm studying.)
15. **A. But** (Sarah wants to visit the museum. **But**, she doesn't have enough money to pay for a ticket.)
16. **A. Because of** (**Because of** the noise, the baby couldn't sleep.)
17. **D. therefore** (She studied hard for the exam, **therefore** she got an A.)
18. **A. but** (The hotel had a great location, **but** the room was small.)
19. **D. Despite** (**Despite** the long queue, she waited patiently to buy the tickets.)
20. **C. although** (**Although** he was afraid of heights, he still went bungee jumping.)
21. **A. therefore** (It was raining outside, **therefore**, we decided to stay indoors.)
22. **A. despite** (**Despite** the high price, the product sold well in the market.)
23. **C. so** (She was tired, **so**, she couldn't fall asleep.)
24. **D. although** (**Although** the weather was bad, they still went camping.)
25. **C. like** (**Like** my brother, I love soccer.)
26. **A. However** (The weather was beautiful, **however**, I didn't feel like going outside.)
27. **D. because** (The train was delayed **because** there was a problem on the tracks.)
28. **A. However** (The restaurant had great reviews, **however**, the service was disappointing.)
29. **B. so** (Peter was tired, **so** he went to bed early.)
30. **D. because** (The kids couldn't play outside **because** it was raining heavily.)
31. **A. despite** (**Despite** the lack of experience, he managed to get the job.)
32. **C. despite** (**Despite** the heavy rain, John still went for a run.)
33. **B. but** (Sarah was feeling sick, **but** she went to work anyway.)
34. **D. Despite** (**Despite** her efforts, she couldn't finish the project on time.)
35. **C. but** (The weather was hot, **but** we still went for a walk.)
36. **D. However** (The project was challenging, **however**, the team managed to complete it on time.)
37. **B. However** (He studied hard for the test, **however**, he still didn't pass.)
38. **D. although** (She didn't want to eat the cake **although** she was on a diet.)
39. **A. therefore** (He slept late last night, **therefore**, he was tired this morning.)
40. **B. However** (The restaurant was busy, **however**, the food was served quickly.)
41. **D. However** (He is usually a careful driver, **however**, he got into an accident yesterday.)
42. **B. although** (**Although** they had been dating for years, they decided to break up.)
43. **A. therefore** (We had a lot of work to do, **therefore**, we decided to stay late at the office.)
44. **D. despite** (**Despite** the fact that she was sick, Sarah went to work.)
45. **B. despite** (**Despite** she didn't have much experience, she got the job.)
46. I noticed your message got cut off. If you were looking to continue with question 46 or wanted to provide further details, feel free to let me know!

If you need more assistance or clarification on any of the questions or transformations, feel free to ask!