You can combine the sentences using "although" and "despite" to show the contrast between his challenging life and his determination to study well. Here’s how you can do it:

1. **Using "although":**
- **Although his life is hard, he is determined to study well.**

2. **Using "despite":**
- **Despite his hard life, he is determined to study well.**

You can combine the sentences using "although" and "despite" to show the contrast between his challenging life and his determination to study well. Here’s how you can do it:

1. **Using "although":**
- **Although his life is hard, he is determined to study well.**

2. **Using "despite":**
- **Despite his hard life, he is determined to study well.**